Alzheimer’s disease

Alzheimer’s disease (AD) is a degenerative neurological degenerative disease that develops insidiously. Clinically, it is characterized by memory impairment, aphasia, indiscriminateness, loss of recognition, visual spatial impairment, executive dysfunction, and changes in personality and behavior, and the etiology has not been known so far. Before the age of 65, the disease is called Alzheimer’s disease; after the age of 65, the disease is called Alzheimer’s disease.

Cause

The disease may be a heterogeneous disease that develops under a variety of factors, including biological and psychosocial factors. According to the current research, there are more than 30 possible factors and hypotheses of the disease, such as family history, female, head trauma, low education level, thyroid disease, too high or too low maternal age, and viral infection. The following factors are related to the onset of the disease:

1.Family history

Most epidemiological studies suggest that family history is a risk factor for the disease. Some of the family members of the family suffer from the same disease than the general population, and the risk of congenital disease is increased. Further genetic studies have confirmed that the disease may be caused by autosomal dominant genes. Recently, through gene mapping studies, it was found that the pathogenic gene of amyloid in the brain is located on chromosome 21. It can be seen that dementia is related to heredity.

The congenital type (DS) has a pathological change similar to this disease. If DS occurs to an adult, the probability of the disease is about 100%. It is known that the DS pathogenic gene is located on chromosome 21, which is of great interest in the genetic study of the disease. However, the genetics of the disease is difficult to study, and most researchers have found that the risk of family members is about 3 to 4 times higher than that of the general population. St. George-Hyslop et al. (1989) reviewed the family data of the disease and found that family members were at risk of developing the disease, with 14.4% of parents and 3.8% to 13.9% of siblings. Using life-time statistical analysis, the risk of first-degree relatives of FAD was as high as 50%, while that of the compare group was only 10%. These data support some of the early onset of FAD, which is a group of age-related dominant autosomal dominant inheritance; There is a female family with only a disease in the literature. It is rare to rule out X-linked inheritance, and most sporadic cases may be the result of interaction between genetic susceptibility and environmental factors.

The genetic degree points associated with AD are currently known to have at least four of them: the early-onset AD loci are located on chromosomes 2l, 14, and 1, respectively. Corresponding possible pathogenic genes are the APP, S182 and STM-2 genes. The delayed-type AD locus is located on chromosome 19, and the possible pathogenic gene is the apolipoprotein E (APOE) gene.

2. Some physical diseases

Such as thyroid disease, immune system diseases, epilepsy, etc., have been studied as a risk factor for the disease. Those with a history of hypothyroidism have a high relative risk of developing the disease. There is a history of seizures before the onset of the disease. The history of migraine or severe headache has nothing to do with the disease. Many studies have found that the history of depression, especially the history of depression in the elderly, is a risk factor for the disease. A recent case-control study found that in addition to depression, other functional mental disorders such as schizophrenia and paranoid psychosis are also involved. Chemical substances that have been studied as risk factors for this disease include heavy metal salts, organic solvents, insecticides, and pharmaceuticals. The role of aluminum has been a concern because animal experiments have shown that aluminum salts have an impact on learning and memory; epidemiological studies suggest that the prevalence of dementia is related to the amount of aluminum in drinking water. It may accelerate the aging process due to the accumulation of neurotoxins such as aluminum or silicon in the body.

3. Head trauma

Head trauma refers to head trauma with conscious disturbance, and brain trauma has been reported as a risk factor for the disease. Clinical and epidemiological studies suggest that severe brain trauma may be one of the causes of some of the disease.

4. Other

Progressive failure of the immune system, weakening of the body’s detoxification function and lentivirus infection, as well as social and psychological factors such as widowhood, solitary, economic difficulties, and life bumps can be the cause of the disease.

Clinical manifestation

The onset of the disease is slow or insidious, and patients and family members often cannot tell when it will start. More common in the elderly over 70 years old (73 males and 75 females), a small number of patients quickly become clear after physical illness, fracture or mental stimulation. More women than men (female: male 3:1). Mainly manifested as decreased cognitive function, mental symptoms and behavioral disorders, and a gradual decline in daily living ability. It is divided into three periods according to the cognitive ability and the deterioration of bodily functions.

The first stage (1 to 3 years)

For mild dementia. The performance is memory loss, the forgottenness of recent events is prominent; the judgment ability is declining, the patient cannot analyze, think, judge, and handle complicated events; the work or housework is careless, and it is not possible to conduct shopping independently, economic affairs, etc., and social difficulties; Although I can still do some familiar daily work, but it is very difficult to understand new things, emotional indifference, occasional irritability, often suspicious; time-oriented obstacles, can make orientation for the place and characters It is difficult to orientate the geographical location, and the visual space ability of the complex structure is poor; the speech vocabulary is small and the naming is difficult.

The second stage (2 to 10 years)

For moderate dementia. It is characterized by severe damage to the memory of the near and far, the visual space ability of the simple structure is degraded, and the time and place are disordered; there are serious damages in dealing with the problem, distinguishing the similarities and differences of things; not being able to carry out outdoor activities independently, in dressing, personal Health and maintenance of personal instruments need help; can not calculate; various neurological symptoms, visible aphasia, misuse and loss of recognition; emotions from indifference to irritability, often moving around, urinary incontinence in some time.

The third stage (8-12 years)

For severe dementia. The patient has completely relied on the caregiver, severe memory loss, memory of only the fragments; daily life can not take care of themselves, incontinence, silence, limb stiffness, visible cone beam sign positive, strong grip, groping and sucking reflection. Eventually coma, generally died of complications such as infection.

Massage 5 acupuncture points to effectively prevent Alzheimer’s disease

Alzheimer’s disease is also very common in life. Many elderly people will be plagued by this disease, because when this disease occurs, it will bring a lot of troubles to life, and even bring a big one to the family. The burden, so often go to massage some of the acupuncture points in the body, you can effectively prevent Alzheimer’s disease, then how should better go to prevent.

After a study of the history of dementia, it was found that vascular dementia was the majority. In terms of prevention, in addition to having a good lifestyle, here are a few groups of acupuncture points that are easy to learn and easy to learn and can promote cerebral blood circulation for elderly friends to massage, which can prevent Alzheimer’s disease.

  1. Massage the two sides of the Fengci and Yifeng acupuncture points

The Fengci is in the main part, under the occipital bone, slightly lowering the head, and the lower part of the ear is behind the horizontal depression. The Yifeng point is in the depression behind the earlobe. This group can improve the blood supply of the basilar artery.

Extreme treatment to improve systemic nutritional status.

2, massage Sibai points

The Sibai points are in the middle of the lower eyelid, and the depression is about 0.5cm. This point is more qi and blood, which stimulates the hole to have the best effect on intracranial blood supply.

3, massage Yintang point

Yintang is located at the midpoint of the line connecting the two brows. This point has the effect of improving cerebral blood circulation, activating brain cells and enhancing memory.

4, stimulate the Weizhong point

The Weizhong Point is located at the midpoint of the horizontal stripes of the armpits. It belongs to the Taiyang Bladder line. Its meridians can communicate with the brain from the top of the head. This part can be stimulated to the brain, so that the mind can be clean and refreshed.

The above points, once in the morning and evening, once every 20 minutes, can be used interchangeably, each time take a group, long-term adherence, can effectively prevent Alzheimer’s disease, to the age of sorrow, still can be clear-eyed, clear thinking, reflecting agility, you may wish Give it a try.

Effective prevention, this Alzheimer’s disease, you should pay more attention in life, especially some elderly people, you should do some hard work, or some small games of brains, because this can help Older people’s brains are healthier, and they can choose to eat more black foods in life, just like some black sesame seeds or walnuts can help the elderly.

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